KMID : 1001920150570040235
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Journal of Korean Neurosurgical Society 2015 Volume.57 No. 4 p.235 ~ p.241
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Correlation of the Beta-Trace Protein and Inflammatory Cytokines with Magnetic Resonance Imaging in Chronic Subdural Hematomas : A Prospective Study
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Park Ki-Su
Park Seong-Hyun Hwang Sung-Kyoo Kim Chae-Kyung Hwang Jeong-Hyun
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Abstract
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Objective: Magnetic resonance imaging (MRI) of chronic subdural hematoma (CSDH) detects various patterns, which can be attributed to many factors. The purpose of this study was to measure the level of interleukin-6 (IL-6), interleukin-8 (IL-8), and highly specific protein [beta-trace protein (¥âTP)] for cerebrospinal fluid (CSF) in CSDHs, and correlate the levels of these markers with the MRI findings.
Methods: Thirty one patients, treated surgically for CSDH, were divided on the basis of MRI findings into hyperintense and non-hyperintense groups. The concentrations of IL-6, IL-8, and ¥âTP in the subdural fluid and serum were measured. The ¥âTP was considered to indicate an admixture of CSF to the subdural fluid if ¥âTP in the subdural fluid (¥âTPSF)/¥âTP in the serum (¥âTPSER) >2.
Results: The mean concentrations of IL-6 and IL-8 of the hyperintense group (n=17) of T1-WI MRI were 3975.1¡¾1040.8 pg/mL and 6873.2¡¾6365.4 pg/mL, whereas them of the non-hyperintense group (n=14) were 2173.5¡¾1042.1 pg/mL and 2851.2¡¾6267.5 pg/mL (p<0.001 and p=0.004). The mean concentrations of ¥âTPSF and the ratio of ¥âTPSF/¥âTPSER of the hyperintense group (n=13) of T2-WI MRI were 7.3¡¾2.9 mg/L and 12.6¡¾5.4, whereas them of the non-hyperintense group (n=18) were 4.3¡¾2.3 mg/L and 7.5¡¾3.9 (p=0.011 and p=0.011).
Conclusion: The hyperintense group on T1-WI MRI of CSDHs exhibited higher concentrations of IL-6 and IL-8 than non-hyperintense group. And, the hyperintese group on T2-WI MRI exhibited higher concentrations of ¥âTPSF and the ratio of ¥âTPSF/¥âTPSER than non-hyperintense group. These findings appear to be associated with rebleeding and CSF admixture in the CSDHs.
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KEYWORD
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Chronic subdural hematoma, Interleukin, Beta-trace protein, Magnetic resonance imaging
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